Scientific Documentation Herbalene

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Immune Restoration and/or Augmentation of Local Graft Versus Host Reaction by Traditional Chinese Medicinal Herbs.

Yan San, MD. Evan M. Hersh, MD. Moshie Talpaz, MD. Siu-Leung Lee PHD. Wendy Wong, BS. Ti Li Loo, PHD. Gloria M. Mavligit, MD.

The in vitro retroactive effect of aqueous extracts from two traditional Chinese medicinal herbs were studied in 19 cancer patients and in 15 normal healthy donors. Using the local graft versus host (GVH) reaction as a test assay for T-cell function, the extract (10 ug/ml) induced a restored reaction in nine of ten patients with an increase in local GVH reaction from 18.2 +/- 15.8 mm to 112.9 +/- =94.2mm (p<0.01). The extract, likewise effected an immune restoration in nine of 13 cancer patients with an increase in local GVH reaction from 32.3 +/- 36.1 mm to 118 +/- 104.9 (p<0.01). This degree of immune restoration appears to be complete as it equals the local GVH reaction observed among untreated mononuclear cells from normal healthy donors (82.8 +/- 41.lmm, P<0.001). These results suggest that both extracts of the traditional Chinese medicinal herbs contain potent immune stimulants which may provide the rational basis for their therapeutic use as biological response modifiers. Cancer 52:70-73, 1983 The Cellular immune Response is usually impaired in cancer patients, and especially in those with advanced disease. This is further compromised by radiation and/or Chemotherapy. It is therefore theorized that any enhancement of the cellular immune response among such patients could potentially be beneficial if it could only eliminate the detrimental effect induced by chemotherapy or irradiation. Numerous attempts are still being made in the search for effective biological response modifiers intended to favorably modulate or preserve the subnormal immune apparatus of cancer patients. Extensive screening of natural and crobial products such as interferon, retinoids, microbial products and plant extracts are currently receiving a great deal of attention. Traditional Chinese medicinal and pharmacology date back several years and represent empirical experiences in the treatment and prevention of various diseases, including cancer. A number of Chinese herbs collectively known as Fu-zheng therapy, are being used to promote or enhance the natural host defense mechanism in various infectious diseases. Clinical trials with such biological products are currently being conducted in China. This communication describes a remarkable augmentative effect in vitro by two Chinese medicinal herbs on T-cell function as assessed by the local GVH reaction among cancer patients and healthy normal donors. From the university of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute. Department of Clinical Immunology and Biological Therapy and the Department of Developmental Therapies Houston, Texas. And the Department of Chemistry, Texas A&M University, College Station Texas. Supported in part by grant no CA 05831. From the National Cancer Institute, National Institutes of Health and grant no A754 from Welch foundation. [/av_textblock] [/av_one_full]